The defense will takes place

November 23th, 2023. Time: 12.00
In the Auditorium
Place: Aalborg Universitet Hospital North
Reberbansgade 15

After the defense there will be held a reception. All are welcome.

 

Supervisors

Main supervisor:
Professor Ole Bjarne Christiansen
MD, D.M.Sc, Aalborg University Hospital and Aalborg University

Assistant supervisor:
Professor Ulrik Schiøler Kesmodel
MD, PhD, Aalborg University Hospital and Aalborg University

Assessment Committee

Professor Emerita Mary D. Stephenson
MD, M.Sc, University of Illinois Chicago, USA
Head Emerita of Department of Obstetrics and Gynaecology

Professor Kristiina Rull
MD, PhD, University of Tartu, Estonia
Head of Department of Obstetrics and Gynaecology

Professor Lene Dreyer
MD, PhD, Aalborg University Hospital and Aalborg University

 

About the PhD thesis

Recurrent pregnancy loss (RPL) affects 1-2 percent of women, and
the incidence is rising. In only approximately 40 percent of the patients, an RPL risk factor can be found, while in the remaining group
of patients with no known cause, immunological abnormalities are
often found, and they are therefore suspected to be involved in the
pathogenesis of RPL.

This PhD thesis aimed to elaborate on immunological risk factors to
RPL and to test the efficacy of an immunomodulatory treatment with
intravenous immunoglobulin and prednisolone for RPL patients. The
PhD thesis includes five peer-reviewed articles.

Two cross-sectional studies evaluating:

• The association between RPL and sex of older siblings

• The association between RPL, HLA class II, and autoantibody positivity

Two combined cross-sectional and cohort studies evaluating:

• The association between the combination of sex of firstborn child and HLA class II genotype and the pregnancy outcome in RPL patients

• The association between mannose-binding lectin plasma level and RPL and the RPL prognosis

A study protocol for a double-blinded randomized controlled trial testing the effect of prednisolone and intravenous immunoglobulin versus
placebo for women with RPL undergoing artificial reproductive technology treatment.

 

Contact information

You can contact MSc., Marie Møller Jensen if you have any questions about the defense by clicking here on her e-mail.

Caroline Nørgaard-Pedersen
E-mail: C.NoergaardPedersen@RN.DK
Aalborg University Hospital
Department of Obstetrics and Gynaecology
9000 Aalborg, Denmark