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PhD defense by Louise Skau Rasmussen

The Department of Clinical Medicine, Aalborg University and Aalborg University Hospital are pleased to invite to PhD defense by MD, Louise Skau Rasmussen, who will defend the thesis entitled: Prognostic and Therapeutic Aspects of Adenocarcinoma of the Pancreas

Tidspunkt

09.10.2020 kl. 14.00 - 17.00

Beskrivelse

The PhD defense will take place

Wednesday 9 October 2020
Time: 2 pm (CEST)

For registration please write an e-mail to:inst.klinisk.phd@dcm.aau.dk


Supervisors

Ursula G. Falkmer
Senior consultant, Professor, MD, PhD
Departments of Oncology and Clinical Medicine
Aalborg University Hospital,
Aalborg University, Denmark

Mette Karen Yilmaz
Senior consultant, MD
Department of Oncology
Aalborg University Hospital, Denmark

Laurids Østergaard Poulsen
MD, PhD, Clinical Lecturer
Departments of Oncology and Clinical Medicine
Aalborg University Hospital
Aalborg University, Denmark


Assessment Committee

Ole Thorlacius-Ussing (chairman)
Senior consultant, Professor, MD, PhD
Departments of Surgery and Clinical Medicine
Aalborg University Hospital
Aalborg University, Denmark

Mef Christina Nilbert
Senior consultant, Professor, MD, PhD
Molecular Diagnostics of colorectal cancer
Department of Clinical Medicine
Amager-Hvidovre Hospital, Denmark
University of Copenhagen                          

Johan Haux
Senior consultant, Ass. Professor, MD, PhD,
Department of surgery/unit of oncology
Skaraborg Hospital, Skövde,
University of Skövde, Sweden

 

About the PhD thesis

In Denmark, approximately 1000 new patients are diagnosed with

pancreatic cancer (PC) each year. Overall survival (OS) is the most reliable endpoint in malignant diseases and it is important to compare real-world treatment results and OS with those of selected patients in randomised controlled trials (RCTs). This issue was investigated in papers I-III with register data from the Danish Pancreatic Cancer Database (2011-2016).

The results from paper I-III showed that the survival periods found for the patients treated with curative surgery and those treated with palliative chemotherapy were similar or slightly shorter compared to those in the RCTs. The patients treated with only best supportive care showed an extremely short survival.

The search for clinical useful biomarkers is important for patients with PC, as they may contribute to the prediction of survival. This was investigated in paper IV with data from the prospective study “BIOmarkers in patients with Pancreatic Cancer” (2008-2018). We evaluated whether pre-treatment serum vitamin D levels were associated with the levels of the inflammatory serum biomarkers, Interleukin-6, chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, and C-reactive protein as well as OS in patients with PC.

The results from paper IV showed that vitamin D deficiency was associated with increased inflammatory biomarkers in all PC stages. Patients with tumour stage I+II with deficient vitamin D levels had a significantly shorter OS than those with sufficient levels. Deficient vitamin D levels did not influence survival in patients with tumour stage III+IV

In conclusion, the survival periods found for the patients in paper I-III were similar or slightly shorter compared to those in the RCTs. The high proportion of elderly and the more frequent comorbidities in our real-world population could explain this discrepancy. Monitoring of the PC patients in DPCD require more clinical variables to compare new treatment strategies with real-world data.

In paper IV vitamin D deficiency was associated with increased inflammatory biomarkers in all PC stages and could be explained by an anti-inflammatory effect of vitamin D. Vitamin D was shown to be a prognostic biomarker for patients with tumour stage I+II, however future studies are needed to investigate vitamin D supplementation effects on survival.

 

Arrangør

Department of Clinical Medicine, Aalborg University

Adresse

Online via Zoom

Tilmelding inden

07.10.2020 kl. 12.00

Tilmeld dig til

inst.klinisk.phd@dcm.aau.dk

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