PhD defense by Emily Steinkohl
The Department of Clinical Medicine, Aalborg University and Aalborg University Hospital are pleased to invite to PhD defense by MD, Emily Steinkohl, who will defend the thesis entitled: Progression of pancreas morphology in chronic pancreatitis - Exploration of new potential MRI Biomarkers
16.12.2021 kl. 13.00 - 16.00
The PhD defense will take place
Thursday 16th December 2021 at 13:00
Auditorium B, Forskningens Hus, Aalborg University Hospita
Sdr. Skovvej 15, 9000 Aalborg
After the defense there will be held a reception. All are welcome.
Prof. Jens Brøndum Frøkjær, Department of Radiology, Aalborg University Hospital and Department of Clinical Medicine, Aalborg University, Denmark
Prof. Søren Schou Olesen, Department of Gastroenterology and Hepatology, Aalborg University Hospital and Department of Clinical Medicine, Aalborg University, Denmark
Prof. Asbjørn Mohr Drewes, Department of Gastroenterology and Hepatology, Aalborg University Hospital and Department of Clinical Medicine, Aalborg University, Denmark
Prof. Inge Søkilde Pedersen (Chair), Department of Molecular Diagnostics, Aalborg University Hospital and Department of Clinical Medicine, Aalborg University, Denmark
Prof. László Czakó, Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary
Prof. Søren Rafael Rafaelsen, Department of Radiology, University Hospital of Southern Denmark and University of Southern Denmark, Denmark
About the PhD thesis
A better understanding of the underlying mechanisms behind the development and progression of chronic pancreatitis (CP) is necessary to suggest and evaluate new mechanism-based treatments. Moreover, it is essential to identify new methods to detect very mild structural damage and, as a result, diagnose CP in earlier stages; thus, early interventions can be undertaken to prevent the progression of CP as early as possible.
Study I was a longitudinal study that assessed morphological pancreatic changes over a four-year follow-up, using quantitative MRI. The main finding of this study showed a pronounced progression of the parenchymal-related parameters during the follow-up period. In contrast, the ductal-related parameters were stable and did not change over the period. Moreover, it was demonstrated that the disease burden was not connected to the morphological progression.
In the cross-sectional Study II new potential MRI biomarkers for the diagnosis and staging of CP were obtained and evaluated. It was shown that T1 relaxation time and MRE-derived stiffness had a very high diagnostic performance in detecting different stages of CP. Moreover, they likely reflect aspects of fibrotic processes in CP and might be considered non-invasive biomarkers for quantifying early fibrotic changes in CP patients.
Overall, Study provides a deeper understanding of the disease progression in CP, whereas Study II propose new MRI biomarkers for use in diagnosing and staging the earlier stages of the CP disease. This knowledge contributes to improving insight into understanding the complex CP disease and points into the direction of a paradigm change in the diagnosis of early CP.
Department of Clinical Medicine, Aalborg University and Aalborg University Hospital
Forskningens Hus, Sdr. Skovvej 15, 9000 Aalborg, Auditorium B