Forskning
Samarbejde

PhD defense by Caspar Bundgaard-Nielsen

The Department of Clinical Medicine, Aalborg University and North Denmark Regional Hospital are pleased to invite to PhD defense by Caspar Bundgaard-Nielsen, who will defend the thesis entitled: GUT AND NEURODEVELOPMENT: The role of gut microbiota dysbiosis in attention-deficit hyperactivity disorder and autism spectrum disorder

Tidspunkt

31.01.2022 kl. 14.00 - 17.00

Beskrivelse

The PhD defense will take place

Monday the 31st of January 2022 at 14:00
Online via Zoom: https://aaudk.zoom.us/j/68570255417

Supervisors

Associate Professor Suzette Sørensen, MSc, PhD
Centre for Clinical Research, North Denmark Regional Hospital
Department of Clinical Medicine, Aalborg University

Clinical Professor Søren Hagstrøm, MD, PhD
Department of Pediatrics, Aalborg University Hospital
Department of Clinical Medicine, Aalborg University

Professor Mette Nyegaard, MSc, PhD
Department of Health Science and Technology, Aalborg University
 

Assessment Committee

Associate Professor Gry Kjærsdam Telléus, MSc, PhD
Aalborg University Hospital – Psychiatry
Department of Clinical Medicine, Aalborg University

Associate Professor Alejandro Arias Vasquez, MSc. PhD
Departments of Human Genetics, Psychiatry and Cognitive Neuroscience,
Radboud University Medical Center

Associate Professor Mani Arumugam, MSc., PhD
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen

 

About the PhD thesis

The PhD thesis is based on three papers, which aimed to investigate the involvement of gut bacteria in the neurodevelopmental disorders attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). A methodological study to test the feasibility of home-sampling, a systematic review to provide an overview of previ-ous studies investigating the role of gut microbiota in ADHD and ASD, and a clinical study investigating the role of gut microbiota in children with ADHD and/or ASD in parallel.

In study 1, we determined that the gut microbiota composition could be maintained for at least 72 hours, through freezing fecal samples in a home-freezer at -20 °C or using storage buffers. This allows the use of home-sampled fecal samples for gut microbiota studies.

In Study 2, we observed conflicting reports on the association be-tween ADHD and gut microbiota. Conversely, several studies ob-served general gut microbiota variations in children with ASD pre-sented with gut microbiota variations, although a specific gut microbi-ota signature could not be established. Despite clinical overlaps be-tween the disorders, no previous study examined the gut microbiota of children with ADHD and ASD in parallel.

Finally, in study 3, we demonstrated that children with ADHD or ASD shared a gut microbiota signature, distinct from non-related control children. Furthermore, children with ADHD or ASD had indicators of increased gastrointestinal permeability.

Collectively, these papers contribute to a growing body of literature that seeks to investigate how the gut microbiota influences neurode-velopment.

Arrangør

Department of Clinical Medicine, Aalborg University, And North Denmark Regional Hospital, Hjørring

Mere information

https://aaudk.zoom.us/j/68570255417

Gå til arrangementslisten

Arrangementer

Se listen