PhD defense by Anne-Marie Wegeberg


11.09.2020 kl. 13.00 - 16.00


The PhD defense will take place

Friday the 11th of September 2020 at 1:00 pm

Because of COVID-19, the PhD defense will be held online.
For registration please write an e-mail to: inst.klinisk.phd@dcm.aau.dk



Professor Christina Brock
Aalborg University and Aalborg University Hospital, Denmark

Professor Asbjørn Mohr Drewe
Aalborg University Hospital, Denmark

Associate Professor Birgitte Brock
Steno Diabetes Center Copenhagen, Denmark

Associate Professor Adam Farmer
University Hospitals of North Midlands and
Queen Mary, University of London, UK

Assessment Committee

Dr. Lone Larsen
Aalborg University Hospital, Denmark

Professor Annelli Sandbæk
Aarhus University & Steno Diabetes Center Aarhus,
Aarhus University Hospital, Denmark

Professor Vincenza Spallone
University of Rome Tor Vergata, Italy

About the PhD thesis

Type 1 diabetes characterized by insulin deficiency affects up to 50 million people worldwide. It is accompanied by an array of debilitating complications, which may develop early in the course of diabetes. The most prevalent and burdensome of these are neuropathies, affecting all parts of the nervous system, and often underrecognized as symptoms are diverse or absent.

The purpose of this PhD thesis was to use existing methodological platforms to recognize and assess the severity of diabetic autonomic neuropathies in the cardiovascular and gastrointestinal systems of adults with type 1 diabetes.

The four papers presented in the thesis contributes insight into clinically applicable tests for assessing cardiovascular autonomic neuropathy and diabetic gastro-enteropathy. Additionally, it provides evidence regarding the interaction between systemic low-grade inflammation and the presence of cardiovascular autonomic neuropathy. Finally, it suggests a beneficial role of the GLP-1 agonist liraglutide on colonic motility and function. Prospectively, these results may help the clinician recognize diabetic autonomic neuropathy earlier. Furthermore, mechanism-based treatments may debilitate symptoms and lay the foundation for future targeted treatments. If succeeded, this will lead to diminished mortality, improved individual quality of life, and reduced medical cost associated with type 1 diabetes.

The thesis is based on three published peer-reviewed papers and an additional paper, which is under review. The four papers are compiling data from two studies; a longitudinal study and a cross-sectional study. The main results will be presented at the PhD defense.


Department of Clinical Medicine


Online via Skype for Business or Zoom

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10.09.2020 kl. 13.00

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