Forskning
Samarbejde

PhD defense, Louise Ladebo

The Department of Clinical Medicine, Aalborg University and Aalborg University Hospital are pleased to invite to PhD defense by M.Sc. (Pharm), Louise Ladebo, who will defend the thesis entitled: Impact of Gastrointestinal Surgery on Absorption of Oxycodone Experimental studies in patients with Roux-en-Y gastric bypass and short bowel syndrome

Tidspunkt

21.06.2021 kl. 14.00 - 17.00

Beskrivelse

The PhD defense will take place

Monday June 21st, 2021, Time: 2 pm

Place: Auditorium Nord, Aalborg University Hospital (North)
and online via teams (registration to: inst.klinisk.phd@dcm.aau.dk)

Please be aware that attending requires that you are vaccinated or have a negative corona-test.

After the defense there will be held a reception. All are welcome

 

Supervisors

Prof. Anne Estrup Olesen, PhD, M.Sc. (Pharm)
Aalborg University Hospital
Aalborg University, Denmark

Prof. Asbjørn Mohr Drewes, MD, DM.Sc., PhD
Aalborg University Hospital
Aalborg University, DenmarK

Prof.Emer. Lona Louring Christrup, PhD, M.Sc. (Pharm)
University of Copenhagen, Denmark


Assessment Committee

Prof. Karen Dybkær, PhD, M.Sc. (chair)
Aalborg University Hospital
Aalborg University, Denmark

Prof. Kim Peder Dalhoff, MD, DM.Sc.
University of Copenhagen, Denmark                                    

Prof. Thorsten Lehr, PhD, M.Sc. (Pharm)
Saarland University, Germany

 

About the PhD thesis

Gastrointestinal surgery, associated with resection or bypass, challenges the use of orally administered drugs, as drug absorption may be altered and cause inadequate efficacy and potentially severe side-effects. Oxycodone is one of the most commonly used opioids for treatment of moderate to severe pain. The aim of this PhD thesis was therefore to investigate the impact of gastrointestinal surgery on the pharmacokinetics and pharmacodynamics of different oral oxycodone formulations, as a model for drug absorption in general.

The thesis includes five original manuscripts. The first manuscript compares pH, transit time and motility measures of the different gastrointestinal regions in patients with Roux-en-Y gastric bypass to healthy volunteers. The following two manuscripts evaluates the exposure-response relationship of oral solution, lipid-based and water-swellable controlled-release oxycodone in healthy participants and patients with gastric bypass, using a pharmacokinetic-pharmacodynamic modelling approach. The fourth manuscript describes and verifies a physiological-based pharmacokinetic model with extensive absorption characteristics for oral solution and controlled-released oxycodone in a healthy population. The model is also used to predict pharmacokinetic outcomes in healthy populations of varying age, ethnicity as well as in patients with renal and hepatic impairment. The last manuscript explores the magnitude of varying intestinal lengths on the absorption degree of oral solution oxycodone by performing a pharmacokinetic study in patients with short bowel syndrome.

Future studies may apply the results to further develop physiological-based pharmacokinetic models in patients with different gastrointestinal diseases and assist individualization of drug therapy.

Arrangør

Department of Clinical Medicine, Aalborg University

Adresse

Auditorium Nord, Reberbansgade 15, 9000 Aalborg

Tilmeld dig til

inst.klinisk.phd@dcm.aau.dk

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