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Ph.d. forsvar ved Gowsini Joseph

The Department of Clinical Medicine, Aalborg University, and Department of Cardiology, North Denmark Regional Hospital, Hjørring, are pleased to invite to PhD defense by Gowsini Joseph, MD, who will defend the thesis entitled: Population study of physical activity and association with tissue Doppler echocardiography, left ventricular mass, hypertension, and long-term outcome: The Copenhagen City Heart Study


22.09.2020 kl. 13.00 - 16.00


The PhD defense will take place

Tuesday, September 22, 2020. Time: 1 pm (CEST)
Moderator: Professor emeritus Ulrik Baandrup, MD, PhD

Because of COVID-19, the PhD defense will be held online
For registration, please write an e-mail to inst.klinisk.phd@dcm.aau.dk no later than September 21, 2020.


Peter Søgaard, MD, DMSc
Department of Clinical Medicine, Aalborg University

Rasmus Møgelvang, MD, PhD
Department of Cardiology, Rigshospitalet, University of Copenhagen

Jacob Louis Marott, MSc
The Copenhagen City Heart Study, Bispebjerg-Frederiksberg Hospital,
University of Copenhagen

Gitte Nielsen, MD, PhD
Department of Cardiology, North Denmark Regional Hospital

†Jan Skov Jensen, MD, PhD, DMSc
Department of Cardiology, Herlev-Gentofte Hospital, University of Copenhagen


Assessment Committee

Håvard Dalen, MD, PhD
Department of Circulation and Medical Imaging, Faculty of Medicine and Health
Science, Norwegian University of Science and Technology, Trondheim, Norway
Clinic of Cardiology, St. Olavs University Hospital, Trondheim, Norway
Department of Medicine, Levanger Hospital, Levanger, Norway

Jørgen Lykke Jeppesen MD, DMSc
Department of Medicine, Amager-Hvidovre Hospital in Glostrup,
University of Copenhagen, Glostrup, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences,
University of Copenhagen, Copenhagen, Denmark

Helle Damgaard Zacho, MD, PhD (chair)
Department of Nuclear Medicine, Aalborg University Hospital,
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark


About the PhD thesis

Physical inactivity is one of the major causes of global death. Physical activity is associated with reduction of cardiovascular disease and mortality. Another threat to global health is hypertension. The WHO has declared hypertension to be the leading cause of global death. The prevalence of hypertension is increasing, both in Western countries and in developing countries, advancing it to a major public health problem. Public health interventions with low economic cost are needed.

This thesis includes studies in the fields of physical activity, cardiac function, and hypertension.

The first study describes how the association between the level of physical activity and cardiac function is dependent on age.

The second study clarifies how the association between physical activity and reduction in mortality has a dose-response pattern at all levels of blood pressure (BP). The important message is that most of the health benefits are already achieved at a light level of physical activity, which is an activity level almost everyone can achieve. Previously, many physicians had
precautions in recommending physical activity for persons in stage 2 hypertension. The main results in this study were persistent for persons in stage 2 hypertension (BP ≥ 160/100 mmHg) as well as the subgroup of patients with BP >180/110 mmHg. It should be noted that the current ESCguidelines do not recommend physical activity in BP>180/110 mmHg.

The third study explores the impact of physical activity in a high-risk population: hypertensive patients with left ventricular hypertrophy. Higher levels of physical activity were associated with a higher left ventricular mass in normal BP, whereas this association was not present in persons with hypertension. After a mean follow-up of 12 years, we found that higher levels of physical activity were associated with a reduction in all-cause mortality and especially cardiovascular endpoints independent of whether left ventricular hypertrophy was present.

Besides raising important questions on the association between physical activity and cardiac performance, this thesis provides new scientific knowledge on the importance of physical activity in the treatment of hypertension, including the subgroups of high-risk hypertensive patients.


Department of Clinical Medicine, Aalborg University

Tilmelding inden

21.09.2020 kl. 12.00

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