Ph.D. Defense by Kasper Sørensen
Kasper Sørensen will defend his Ph.D. thesis “Seismocardiography: Interpretation and Clinical Application”
17.09.2021 kl. 14.00 - 17.00
14.00 Opening by the Moderator Samuel Emil Schmidt
14.05 PhD lecture by Kasper Sørensen
15.00 Questions and comments from the Committee
Questions and comments from the audience at the Moderator’s discretion
17.00 Conclusion of the session by the Moderator
The Faculty Council has appointed the following adjudication committee to evaluate the thesis and the associated lecture:
Research Director Alfredo Ignacio Hernandez Rodriguez, French Institutes of Health and Medical Research, INSERM, France
Associate Professor Hansen A. Mansy, University of Central Florida, Department of Mechanical and Aerospace Engineering., USA
Associate Professor Carsten Dahl Mørch, Aalborg University, Denmark
Associate Professor Samuel Emil Schmidt, Aalborg University, Denmark
Cardiovascular disease (CVD) is the leading cause of death and in Europe alone it is accountable for 3.9 million deaths every year. Even though the number of deaths is declining, morbidity is not, leading to the low quality of life for the people affected by the disease.
A wide variety of diagnostic tools for CVD exist, each within their field of application.
In this project, the method of recording cardiac vibrations non-invasively on the sternum, called seismocardiography (SCG), is investigated.
The first study investigates the origin of the signal with respect to the underlying physiology determined with echo from 45 healthy subjects. This study contributes to the overall understanding of the correlation between deflections in the signal and physiologic events in the cardiac cycle. The second study focuses on the manifestation of the signal in patients with cardiac resynchronization therapy (CRT) pacemakers. Further, the study explores the possibility of using SCG for optimization of the pacing delay setting of the pacemaker. The third study evolves around the correlation between features in the SCG signal and cardiorespiratory fitness (CRF).
Study I demonstrate the physiologic connection between the SCG, and events found in echo. Eight fiducial points in the SCG have short temporal distance and high correlation to eight physiologic events found in echo. Study II shows how the mechanical dyssynchrony manifests in the SCG signal and how cardiac time intervals that are derived from the SCG changes with different pacing settings. In Study III, gold standard VO2max was measured, and a model for non-exercise VO2max estimation with the SCG signal was developed.
The SCG carries complex and valuable information about the cardiac mechanics. This thesis identifies some of the underlying physiological origin of the signal and demonstrates two clinical use cases for the method: Bi-ventricular pacemaker optimization and estimation of VO2max.
Department of Health Science and Technology, The Faulty of Medicine, Aalborg University
The Ph.D. Defense is organized as a hybrid event - digitally via Zoom and physical presence in room D2-106, Frederik Bajers Vej 7 D2, Aalborg Ø
15.09.2021 kl. 12.00